4/26/2023 0 Comments Assan ohda mukh vekhnaA principal component analysis of the behaviour profile confirms that the 6‐OHDA mouse model displayed good face and predictive validity. A histological analysis further supports the model validity by indicating dopamine depletion, changes in cortical thickness and abnormalities in anterior cingulate cortex neurons. The efficacy of methylphenidate, a classical psychostimulant used in the treatment of ADHD, was also evaluated. anxiety‐like (elevated plus maze test) and antisocial (social interaction) behaviours and decreased cognitive functioning (novel object recognition). ![]() Further, the model revealed discrete co‐existing symptoms, i.e. hyperactivity (open field), attention deficit and impulsivity (five‐choice serial reaction time task). 6‐OHDA mice exhibited the major ADHD‐like symptoms, i.e. Our aim was to analyse symptoms of ADHD in the mouse neonatal 6‐OHDA model. However, a comprehensive assessment of ADHD‐like symptoms is still missing, and data in mouse remain largely unavailable. ![]() The “neonatal 6-hydroxydopamine” (6-OHDA) lesion is a commonly used model of ADHD in rat. ![]() ![]() Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by impaired attention, impulsivity and hyperactivity.
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